lemon juice as a biocatalyst in sythesis of bis-indolilmethanes

Author: shalva mchedlidze
Keywords: bis-indolilmethane, biocatalyst, lemon juice, green chemistry
Annotation:

Nowadays, conducting reactions based on the concept of green chemistry is highly relevant. In this paper, an efficient and environmentally friendly method of synthesizing 3,3-(phenylmethylene)-bis-2-phenyl-1H-indole has been developed through the condensation of 2-phenylindole and benzaldehyde. To optimize the reaction conditions, the synthesis was carried out under various conditions, specifically: in a mixture of lemon juice and water, lemon juice, and a mixture of alcohol (95%) and water, both on a room temperature and at 60°C. It is noteworthy that the best result was obtained when using a mixture of lemon juice, alcohol (95%), and water in a ratio of 1:1.5:2.5 at a temperature at 800C