Determination of antibiotic and phage sensitivity of clinical strains of Pseudomonas aeruginosa

Author: nato zardiashvili
Keywords: Pseudomonas aeruginosa
Annotation:

Pseudomonas aeruginosa is a representative of the genus Pseudomonas. This genus includes more than 20 species. Among them, some are natural inhabitants of the soil and play an important role in the circulation of substances, while others are the cause of human, animal and plant pathologies. [1] P. aeruginosa is a multidrug-resistant, opportunistic pathogen. Microbial infections are associated with otitis media, conjunctivitis, wound infections, pneumonia, septic arthritis, fibrotic cystitis, and others. Often spread from water and disinfectant fluids, its role in the etiology of neonatal infections has increased. Infections caused by this microbe also took one of the leading places among nosocomial and opportunistic diseases in oncological, burn and other immunodeficiency patients. In immunocompromised and cancer patients, it causes a high mortality rate. One of the reasons for the latter is the colonization of the intestinal epithelial tissue by virulent strains of P. aeruginosa and the ability to form biofilms (Marshall et al., 1993; Alverdy et al., 2000). Infections caused by pathogens are also associated with plant and animal diseases. P. aeruginosa is the most common bacterium in patients with fibrotic cystitis. After entering the respiratory tract, it easily colonizes the lungs, which leads to chronic infection (pneumonia), decreased lung function, which is often fatal. Long-term and aggressive treatment with appropriate antibiotics can reduce the development of long-term infection. That is why timely diagnosis of pseudomonas and proper treatment are important. The widespread distribution of P. aeruginosa is due to their resistance to various adverse environmental factors and resistance to many drugs. The spread of antibiotic-resistant bacterial strains creates significant difficulties in the treatment of infectious processes. Therefore, it is particularly important to use phage preparations against infections caused by antibiotic-resistant P. aeruginosa. The aim of the presented work was to determine the antibiotic and phage sensitivity of clinical strains of P. aeruginosa.