SYNTHESIS OF SILICON N-GaLACTOSILAMINES

Annotation Aitaj Japarova SYNTHESIS OF SILICON N-GaLACTOSILAMINES Iv. Javakhishvili Tbilisi’s State University, Departament of Chemistry I.Chavchavadze ave.3 In order to obtain biological active compounds, we have devised a new metod for synthesizing silicon containing N-glycosides. Modification of known medicinal preparations with silicon atoms can result significant changes in chemical character and biological properties. We have studied the reaction of chlorosilylation of N-galactopyranosylamine. N-β-(p-tolyl)-2,3,4,6-tetra-O-acetyl-D-galactopyranosilamine (2) was obtained by acetylation of N-β-(p-tolyl)-D-galactopiranosylamine (1) with acetic anhydride and pyridine. By of compound (2) with triphenylchlorosilane in the presence of zinc dustat at room temperature corresponding N-β-(p-tolyl)-N-trimethylsilyl-2,3,4,6-tetra-O-acetyl-D-galactopyranosilamines were synthesized for the first time. The reactions is carried out according to the following schem: The structures of obtained compounds were established by physical-chemical methods of analysis (IR spectroscopy).